| Host: |
Goat |
| Applications: |
Pep-ELISA |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Goat polyclonal antibody anti-MARCH2/MARCH-II (Internal) is suitable for use in ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: |
Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: |
0.5 mg/mL |
| Dilution Range: |
ELISA-antibody detection limit dilution 1:16000. |
| Storage Instruction: |
Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: |
MARCHF2 |
| Gene ID: |
51257 |
| Uniprot ID: |
MARH2_HUMAN |
| Immunogen Region: |
Internal |
| Accession Number: |
NP_001005415.1; NP_001005416.1; NP_057580.3 |
| Immunogen Sequence: |
KIREADSPEGPQH |
| Function | E3 ubiquitin-protein ligase that may mediate ubiquitination of TFRC and CD86, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. Together with GOPC/CAL mediates the ubiquitination and lysosomal degradation of CFTR. Ubiquitinates and therefore mediates the degradation of DLG1. Regulates the intracellular trafficking and secretion of alpha1-antitrypsin/SERPINA1 and HP/haptoglobin via ubiquitination and degradation of the cargo receptor ERGIC3. Negatively regulates the antiviral and antibacterial immune response by repression of the NF-kB and type 1 IFN signaling pathways, via MARCHF2-mediated K48-linked polyubiquitination of IKBKG/NEMO, resulting in its proteasomal degradation. May be involved in endosomal trafficking through interaction with STX6. (Microbial infection) Positively regulates the degradation of Vesicular stomatitis virus (VSV) G protein via the lysosomal degradation pathway. Represses HIV-1 viral production and may inhibit the translocation of HIV-1 env to the cell surface, resulting in decreased viral cell-cell transmission. |
| Protein Name | E3 Ubiquitin-Protein Ligase Marchf2Membrane-Associated Ring Finger Protein 2Membrane-Associated Ring-Ch Protein IiMarch-IiRing Finger Protein 172Ring-Type E3 Ubiquitin Transferase Marchf2 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinLysosome MembraneEndosome MembraneGolgi Apparatus MembraneCytoplasmCell Membrane |
| Alternative Antibody Names | Anti-E3 Ubiquitin-Protein Ligase Marchf2 antibodyAnti-Membrane-Associated Ring Finger Protein 2 antibodyAnti-Membrane-Associated Ring-Ch Protein Ii antibodyAnti-March-Ii antibodyAnti-Ring Finger Protein 172 antibodyAnti-Ring-Type E3 Ubiquitin Transferase Marchf2 antibodyAnti-MARCHF2 antibodyAnti-MARCH2 antibodyAnti-RNF172 antibodyAnti-HSPC240 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
