| Function | Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. |
| Protein Name | Target Of Rapamycin Complex 2 Subunit Mapkap1Torc2 Subunit Mapkap1Mitogen-Activated Protein Kinase 2-Associated Protein 1Stress-Activated Map Kinase-Interacting Protein 1Sapk-Interacting Protein 1Msin1 |
| Database Links | Reactome: R-HSA-1257604Reactome: R-HSA-389357Reactome: R-HSA-5218920Reactome: R-HSA-5674400Reactome: R-HSA-6804757 |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCytoplasmic VesicleNucleus |
| Alternative Antibody Names | Anti-Target Of Rapamycin Complex 2 Subunit Mapkap1 antibodyAnti-Torc2 Subunit Mapkap1 antibodyAnti-Mitogen-Activated Protein Kinase 2-Associated Protein 1 antibodyAnti-Stress-Activated Map Kinase-Interacting Protein 1 antibodyAnti-Sapk-Interacting Protein 1 antibodyAnti-Msin1 antibodyAnti-MAPKAP1 antibodyAnti-MIP1 antibodyAnti-SIN1 antibody |
Information sourced from Uniprot.org
