| Post Translational Modifications | Palmitoylated. Probably depalmitoylated by ABHD17A, ABHD17B and ABHD17C. During neuronal polarization, palmitoylation and depalmitoylation cycles regulate MAP6 shuttling between secretory vesicles and microtubules, and its polarized distribution in the axon. |
| Function | Involved in microtubule stabilization in many cell types, including neuronal cells. Specifically has microtubule cold stabilizing activity. Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B. Regulates KIF5A-mediated axonal cargo transport. Regulates axonal growth during neuron polarization. |
| Protein Name | Microtubule-Associated Protein 6Map-6Stable Tubule-Only PolypeptideStop |
| Cellular Localisation | CytoplasmCytoskeletonGolgi ApparatusCell ProjectionAxonDendriteCytoplasmic VesicleSecretory Vesicle MembraneLipid-AnchorCytoplasmic SideLocalizes Predominantly In The Proximal Part Of The AxonPreferentially Is Concentrated On A Portion Of The Microtubule Polymer In Which Tubulin Is Modified By Detyrosination And Acetylation And Is Also Resistant To Depolymerization Induced By Both Nocodazole And ColdIn Unpolarized NeuronsLocalizes To The Golgi And To Secretory Vesicles Accumulating Transiently At The Tips Of A Subset Of NeuritesFollowing Neuronal Polarization And During Axon OutgrowthAccumulates In The Axonal Growth Cone And Subsequently Localizes Throughout The AxonPartially Localizes To Dendrites In Mature NeuronsColocalizes With Neurofilament (Nf)-Rich Inclusions In Spinal Cord And Brain Neurons Of Patients With Amyotrophic Lateral Sclerosis (Als) |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 6 antibodyAnti-Map-6 antibodyAnti-Stable Tubule-Only Polypeptide antibodyAnti-Stop antibodyAnti-MAP6 antibodyAnti-KIAA1878 antibody |
Information sourced from Uniprot.org
