Host: | Rabbit |
Applications: | WB |
Reactivity: | Human |
Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: | Rabbit polyclonal antibody anti-MAP4K4 (480-650) is suitable for use in Western Blot research applications. |
Clonality: | Polyclonal |
Conjugation: | Unconjugated |
Isotype: | IgG |
Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
Purification: | Affinity purification |
Dilution Range: | WB 1:500-1:2000 |
Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: | MAP4K4 |
Gene ID: | 9448 |
Uniprot ID: | M4K4_HUMAN |
Immunogen Region: | 480-650 |
Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 480-650 of human MAP4K4 (NP_663719.2). |
Immunogen Sequence: | EVLQQQLLQEQAMLLHDHRR PHPQHSQQPPPPQQERSKPS FHAPEPKAHYEPADRAREVE DRFRKTNHSSPEAQSKQTGR VLEPPVPSRSESFSNGNSES VHPALQRPAEPQVPVRTTSR SPVLSRRDSPLQGSGQQNSQ AGQRNSTSSIEPRLLWERVE KLVPRPGSGSS |
Tissue Specificity | Widely expressed. Isoform 5 is abundant in the brain. Isoform 4 is predominant in the liver, skeletal muscle and placenta. |
Function | Serine/threonine kinase that may play a role in the response to environmental stress and cytokines such as TNF-alpha. Appears to act upstream of the JUN N-terminal pathway. Phosphorylates SMAD1 on Thr-322. |
Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 Hpk/Gck-Like Kinase Hgk Mapk/Erk Kinase Kinase Kinase 4 Mek Kinase Kinase 4 Mekkk 4 Nck-Interacting Kinase |
Database Links | Reactome: R-HSA-2559580 |
Cellular Localisation | Cytoplasm |
Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase Kinase 4 antibody Anti-Hpk/Gck-Like Kinase Hgk antibody Anti-Mapk/Erk Kinase Kinase Kinase 4 antibody Anti-Mek Kinase Kinase 4 antibody Anti-Mekkk 4 antibody Anti-Nck-Interacting Kinase antibody Anti-MAP4K4 antibody Anti-HGK antibody Anti-KIAA0687 antibody Anti-NIK antibody |
Information sourced from Uniprot.org