Anti-MAP3K14 antibody [SAA1891] (STJA0020319)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Mitogen-Activated Protein Kinase Kinase Kinase 14 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1891 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | MAP3K14 |
| Gene ID | 9020 |
| Uniprot ID | M3K14_HUMAN |
Additional Info
| Post Translational Modifications | Autophosphorylated. Phosphorylation at Thr-559 is required to activate its kinase activity and 'Lys-63'-linked polyubiquitination. Phosphorylated by CHUK/IKKA leading to MAP3K14 destabilization. Ubiquitinated. Undergoes both 'Lys-48'- and 'Lys-63'-linked polyubiquitination. 'Lys-48'-linked polyubiquitination leads to its degradation by the proteasome, while 'Lys-63'-linked polyubiquitination stabilizes and activates it. |
| Function | Lymphotoxin beta-activated kinase which seems to be exclusively involved in the activation of NF-kappa-B and its transcriptional activity. Phosphorylates CHUK/IKKA, thereby promoting proteolytic processing of NFKB2/P100, which leads to NF-kappa-B activation via the non-canonical pathway. Has an essential role in the non-canonical NF-kappa-B signaling that regulates genes encoding molecules involved in B-cell survival, lymphoid organogenesis, and immune response. Could act in a receptor-selective manner. |
| Protein Name | Mitogen-Activated Protein Kinase Kinase Kinase 14Nf-Kappa-Beta-Inducing KinaseHsnikSerine/Threonine-Protein Kinase Nik |
| Database Links | Reactome: R-HSA-389357Reactome: R-HSA-5607761Reactome: R-HSA-5668541Reactome: R-HSA-5676590Reactome: R-HSA-5676594 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Mitogen-Activated Protein Kinase Kinase Kinase 14 antibodyAnti-Nf-Kappa-Beta-Inducing Kinase antibodyAnti-Hsnik antibodyAnti-Serine/Threonine-Protein Kinase Nik antibodyAnti-MAP3K14 antibodyAnti-NIK antibody |
Information sourced from Uniprot.org