| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Host: | Rabbit |
| Reactivity: | Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:100-1:500IHC-P:1:50-1:200IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAP2 |
| Gene ID: | 4133 |
| Uniprot ID: | MTAP2_HUMAN |
| Immunogen Region: | 1-118 |
| Immunogen Sequence: | MADERKDEAKAPHWTSAPLT EASAHSHPPEIKDQGGAGEG LVRSANGFPYREDEEGAFGE HGSQGTYSNTKENGINGELT SADRETAEEVSARIVQVVTA EAVAVLKGEQEKEAQHKD |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-118 of human MAP2 (NP_002365.3). |
| Post Translational Modifications | Phosphorylated at serine residues in K-X-G-S motifs by MAP/microtubule affinity-regulating kinase (MARK1 or MARK2), causing detachment from microtubules, and their disassembly. Isoform 2 is probably phosphorylated by PKA at Ser-323, Ser-354 and Ser-386 and by FYN at Tyr-67. The interaction with KNDC1 enhances MAP2 threonine phosphorylation. |
| Function | The exact function of MAP2 is unknown but MAPs may stabilize the microtubules against depolymerization. They also seem to have a stiffening effect on microtubules. |
| Protein Name | Microtubule-Associated Protein 2Map-2 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell ProjectionDendrite |
| Alternative Antibody Names | Anti-Microtubule-Associated Protein 2 antibodyAnti-Map-2 antibodyAnti-MAP2 antibody |
Information sourced from Uniprot.org
