• Human breast carcinoma stained with anti-Mammaglobin antibody using peroxidase-conjugate and DAB chromogen. Note cytoplasmic staining of tumor glands.

Anti-Mammaglobin Cocktail antibody (Full length) [304‐1A5&31‐A5] (STJ180164)

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STJ180164

£223.50 - £1,065.50
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Host: Mouse, Rabbit
Applications: IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse, Rabbit monoclonal antibody anti-Mammaglobin Cocktail (Full length) is suitable for use in Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: 304‐1A5&31‐A5
Conjugation: Unconjugated
Isotype: Mouse IgG1/Kappa/Rabbit IgG
Formulation: Tris-HCI buffer containing stabilizing protein (BSA) and <0.1% ProClin
Purification: Affinity purified
Dilution Range: 1:50‐100
Storage Instruction: Store at 2‐8°C for up to 24 months. Predilute: Ready to use, no reconstitution necessary. Concentrate: Use dilution range and appropriate lab‐standardized diluent. Stability after dilution: 7 days at 24°C, 3 months at 2‐8°C, 6months at ‐20°C.
Immunogen Region: Full length
Specificity: Positive control: Normal or neoplastic breast tissue
Immunogen: Recombinant full-length protein
Background In normal breast tissue, 304-1A5 and 31A5 labels breast ductal and lobular epithelial cells. In tumor cells, it is reactive with all types of breast adenocarcinoma regardless tumor differentiation and types. Adenocarcinomas from other organs rarely express mammaglobin. Cellular localization: cytoplasmic. Mammaglobin is a breast-associated glycoprotein distantly related to secretoglobin family that includes human uteroglobin and lipophilin. Unlike other secretoglobin family members, mammaglobin mRNA expression is breast specific, which has been shown to be a very sensitive marker of occult breast cancer cells in sentinel lymph nodes and peripheral blood. By paraffin immunohistochemistry, the overall sensitivity of mammaglobin for breast cancers was reported about 80%. When combined with other breast-restricted markers such as GCDFP-15, an overall sensitivity of 84% could be achieved. Mammaglobin can play a contributing role in the identification of primary sites of carcinomas presenting at metastatic sites.

Information sourced from Uniprot.org

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