Anti-MAML2 antibody (750-850) (STJ11102886)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal MAML2 (750-850) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAML2 |
| Gene ID | 84441 |
| Uniprot ID | MAML2_HUMAN |
| Immunogen Region | 750-850 |
| Immunogen Sequence | NQQLMGKKQTLQRQIMEQKQ QLLLQQQMLADAEKIAPQDQ INRHLSRPPPDYKDQRRNVG NMQPTAQYSGGSSTISLNSN QALANPVSTHTILTPNSSLL S |
| Specificity | A synthetic peptide corresponding to a sequence within amino acids 750-850 of human MAML2 (NP_115803.1). |
Additional Info
| Tissue Specificity | Widely expressed with high levels detected in placenta, salivary gland and skeletal muscle. |
| Function | Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Potentiates activation by NOTCH3 and NOTCH4 more efficiently than MAML1 or MAML3. |
| Protein Name | Mastermind-Like Protein 2Mam-2 |
| Database Links | Reactome: R-HSA-1912408Reactome: R-HSA-210744Reactome: R-HSA-2122947Reactome: R-HSA-2197563Reactome: R-HSA-2644606Reactome: R-HSA-2894862Reactome: R-HSA-350054Reactome: R-HSA-8941856Reactome: R-HSA-9013508Reactome: R-HSA-9013695Reactome: R-HSA-9793380 |
| Cellular Localisation | Nucleus SpeckleNuclearIn A Punctate Manner |
| Alternative Antibody Names | Anti-Mastermind-Like Protein 2 antibodyAnti-Mam-2 antibodyAnti-MAML2 antibodyAnti-KIAA1819 antibody |
Information sourced from Uniprot.org