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Anti-MALT1 antibody [EBS-T-007] (STJ16101077)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenA BALB/c mouse was immunized with human MALT1 recombinant protein. Fusion partner: Sp2/0.
General Information
| Short Description | Mouse monoclonal antibody anti-MALT1 is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Applications | WB/IHC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | EBS-T-007 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 ยตg/mL, 500 ยตg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | Immunoblotting (1-2 ยตg/ml). Immunohistology (formalin-fixed: 1-2 ยตg/ml for 30 min at RT; requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min. followed by cooling at RT for 20 min). |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8ยฐC upon receipt. |
Target Information
| Gene Symbol | MALT1 |
| Gene ID | 10892 |
| Uniprot ID | MALT1_HUMAN |
| Immunogen | A BALB/c mouse was immunized with human MALT1 recombinant protein. Fusion partner: Sp2/0. |
Additional Info
| Tissue Specificity | Highly expressed in peripheral blood mononuclear cells. Detected at lower levels in bone marrow, thymus and lymph node, and at very low levels in colon and lung. |
| Function | Protease that enhances BCL10-induced activation: acts via formation of CBM complexes that channel adaptive and innate immune signaling downstream of CARD domain-containing proteins (CARD9, CARD11 and CARD14) to activate NF-kappa-B and MAP kinase p38 pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Mediates BCL10 cleavage: MALT1-dependent BCL10 cleavage plays an important role in T-cell antigen receptor-induced integrin adhesion. Involved in the induction of T helper 17 cells (Th17) differentiation. Cleaves RC3H1 and ZC3H12A in response to T-cell receptor (TCR) stimulation which releases their cooperatively repressed targets to promote Th17 cell differentiation. Also mediates cleavage of N4BP1 in T-cells following TCR-mediated activation, leading to N4BP1 inactivation. May also have ubiquitin ligase activity: binds to TRAF6, inducing TRAF6 oligomerization and activation of its ligase activity. |
| Protein Name | Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1Malt Lymphoma-Associated TranslocationParacaspase |
| Database Links | Reactome: R-HSA-1169091Reactome: R-HSA-202424Reactome: R-HSA-2871837Reactome: R-HSA-5607764Reactome: R-HSA-5660668 |
| Cellular Localisation | CytoplasmPerinuclear RegionNucleusShuttles Between The Nucleus And CytoplasmFound In Perinuclear Structures Together With Bcl10 |
| Alternative Antibody Names | Anti-Mucosa-Associated Lymphoid Tissue Lymphoma Translocation Protein 1 antibodyAnti-Malt Lymphoma-Associated Translocation antibodyAnti-Paracaspase antibodyAnti-MALT1 antibodyAnti-MLT antibody |
Information sourced from Uniprot.org