Anti-MAGI3 antibody (927-977 aa) (STJ194609)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human MAGI3 at the amino acid range 927-977
General Information
| Short Description | Rabbit polyclonal anti-Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3 (927-977 aa) for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAGI3 |
| Gene ID | 260425 |
| Uniprot ID | MAGI3_HUMAN |
| Immunogen | Synthesized peptide derived from the human MAGI3 at the amino acid range 927-977 |
| Immunogen Region | 927-977 aa |
| Specificity | This antibody detects endogenous levels of MAGI3 at Human/Mouse/Rat |
Additional Info
| Post Translational Modifications | Ubiquitinated following interaction with HPV E6 protein, leading to its degradation by the proteasome. Degradation is independent of E6AP ubiquitin ligase complex. |
| Function | Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the JNK signaling cascade via its interaction with FZD4 and VANGL2. |
| Protein Name | Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3Membrane-Associated Guanylate Kinase Inverted 3Magi-3 |
| Database Links | |
| Cellular Localisation | Cell MembranePeripheral Membrane ProteinCell JunctionTight JunctionNucleusConcentrates In Specific Sites At The Plasma Membrane And In The NucleusIn Epithelial CellsIt Localizes At Tight Junctions |
| Alternative Antibody Names | Anti-Membrane-Associated Guanylate Kinase - Ww And Pdz Domain-Containing Protein 3 antibodyAnti-Membrane-Associated Guanylate Kinase Inverted 3 antibodyAnti-Magi-3 antibodyAnti-MAGI3 antibodyAnti-KIAA1634 antibody |
Information sourced from Uniprot.org