| Short Description : | Rabbit polyclonal anti-Melanoma-associated antigen C2 (160-240 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-1:2000ELISA 1:5000 |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAGEC2 |
| Gene ID: | 51438 |
| Uniprot ID: | MAGC2_HUMAN |
| Immunogen: | Synthesized peptide derived from MAGE-C2 at the amino acid range 160-240 |
| Immunogen Region: | 160-240 aa |
| Specificity: | MAGE-C2 Polyclonal Antibody detects endogenous levels of MAGE-C2 protein. |
| Function | Proposed to enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. In vitro enhances ubiquitin ligase activity of TRIM28 and stimulates p53/TP53 ubiquitination in presence of Ubl-conjugating enzyme UBE2H leading to p53/TP53 degradation. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzymes (E2) at the E3:substrate complex. |
| Protein Name | Melanoma-Associated Antigen C2Cancer/Testis Antigen 10Ct10Hepatocellular Carcinoma-Associated Antigen 587Mage-C2 AntigenMage-E1 Antigen |
| Database Links | |
| Cellular Localisation | CytoplasmNucleusNuclear In Germ CellsCytoplasmic In Well-Differentiated Hepatocellular CarcinomaNuclear In Moderately- And Poorly-Differentiated Hepatocellular Carcinoma |
| Alternative Antibody Names | Anti-Melanoma-Associated Antigen C2 antibodyAnti-Cancer/Testis Antigen 10 antibodyAnti-Ct10 antibodyAnti-Hepatocellular Carcinoma-Associated Antigen 587 antibodyAnti-Mage-C2 Antigen antibodyAnti-Mage-E1 Antigen antibodyAnti-MAGEC2 antibodyAnti-HCA587 antibodyAnti-MAGEE1 antibody |
Information sourced from Uniprot.org
