Anti-MAG antibody (501-550 aa) (STJ96882)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG at the amino acid range 501-550
General Information
| Short Description | Rabbit polyclonal anti-Myelin-associated glycoprotein (501-550 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MAG |
| Gene ID | 4099 |
| Uniprot ID | MAG_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the C-terminal region of human MAG at the amino acid range 501-550 |
| Immunogen Region | 501-550 aa |
| Specificity | MAG Polyclonal Antibody detects endogenous levels of MAG protein. |
Additional Info
| Post Translational Modifications | N-glycosylated. Phosphorylated on tyrosine residues. Ubiquitinated, leading to proteasomal degradation. |
| Function | Adhesion molecule that mediates interactions between myelinating cells and neurons by binding to neuronal sialic acid-containing gangliosides and to the glycoproteins RTN4R and RTN4RL2. Not required for initial myelination, but seems to play a role in the maintenance of normal axon myelination. Protects motoneurons against apoptosis, also after injury.protection against apoptosis is probably mediated via interaction with neuronal RTN4R and RTN4RL2. Required to prevent degeneration of myelinated axons in adults.this probably depends on binding to gangliosides on the axon cell membrane. Negative regulator of neurite outgrowth.in dorsal root ganglion neurons the inhibition is mediated primarily via binding to neuronal RTN4R or RTN4RL2 and to a lesser degree via binding to neuronal gangliosides. In cerebellar granule cells the inhibition is mediated primarily via binding to neuronal gangliosides. In sensory neurons, inhibition of neurite extension depends only partially on RTN4R, RTN4RL2 and gangliosides. Inhibits axon longitudinal growth. Inhibits axon outgrowth by binding to RTN4R. Preferentially binds to alpha-2,3-linked sialic acid. Binds ganglioside Gt1b. |
| Protein Name | Myelin-Associated GlycoproteinSiglec-4a |
| Database Links | Reactome: R-HSA-193634Reactome: R-HSA-210991Reactome: R-HSA-9619665 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinMembrane Raft |
| Alternative Antibody Names | Anti-Myelin-Associated Glycoprotein antibodyAnti-Siglec-4a antibodyAnti-MAG antibodyAnti-GMA antibody |
Information sourced from Uniprot.org