| Short Description : | Rabbit polyclonal MAFF (75-164) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | MAFF |
| Gene ID: | 23764 |
| Uniprot ID: | MAFF_HUMAN |
| Immunogen Region: | 75-164 |
| Immunogen Sequence: | QKEELQKQKSELEREVDKLA RENAAMRLELDALRGKCEAL QGFARSVAAARGPATLVAPA SVITIVKSTPGSGSGPAHGP DPAHGPASCS |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 75-164 of human MAFF (NP_036455.1). |
| Tissue Specificity | Expressed in the term myometrium and kidney. |
| Function | Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves. However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene. May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition. |
| Protein Name | Transcription Factor MaffU-MafV-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog F |
| Database Links | Reactome: R-HSA-983231 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcription Factor Maff antibodyAnti-U-Maf antibodyAnti-V-Maf Musculoaponeurotic Fibrosarcoma Oncogene Homolog F antibodyAnti-MAFF antibody |
Information sourced from Uniprot.org
