| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | SRM |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Gene Symbol: | LZTR1 |
| Gene ID: | 8216 |
| Uniprot ID: | LZTR1_HUMAN |
| Immunogen Region: | 300-545 aa |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 300-545 of human LZTR1 (NP_006758.2). |
| Immunogen Sequence: | GGAADNTLPNELHCYDVDFQ TWEVVQPSSDSEVGGAEVPE RACASEEVPTLTYEERVGFK KSRDVFGLDFGTTSAKQPTQ PASELPSGRLFHAAAVISDA MYIFGGTVDNNIRSGEMYRF QFSCYPKCTLHEDYGRLWES RQFCDVEFVLGEKEECVQGH VAIVTARSRWLRRKITQARE RLAQKLEQEAAPVPREAPGV AAGGARPPLLHVAIREAEAR PFEVLMQFLYTDKIKYPRK |
| Post Translational Modifications | Phosphorylated on tyrosine upon induction of apoptosis, leading to its degradation by the proteasome. |
| Function | Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes. |
| Protein Name | Leucine-Zipper-Like Transcriptional Regulator 1Lztr-1 |
| Cellular Localisation | Endomembrane SystemRecycling EndosomeGolgi Apparatus |
| Alternative Antibody Names | Anti-Leucine-Zipper-Like Transcriptional Regulator 1 antibodyAnti-Lztr-1 antibodyAnti-LZTR1 antibodyAnti-TCFL2 antibody |
Information sourced from Uniprot.org