• Western blot analysis of various lysates, using Lyve1 Rabbit polyclonal antibody (STJ11105196) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 60s.

Anti-Lyve1 antibody (30-228 aa) (STJ11105196)

SKU:
STJ11105196

£112.50 - £524.50
Current Stock:
Host: Rabbit
Applications: WB/ELISA
Reactivity: Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Purification: Affinity purification
Concentration: Lot specific
Dilution Range: WB:1:500-1:1000
ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: Lyve1
Gene ID: 114332
Uniprot ID: LYVE1_MOUSE
Immunogen Region: 30-228 aa
Specificity: Recombinant fusion protein containing a sequence corresponding to amino acids 30-228 of mouse Lyve1. (NP_444477.2).
Immunogen Sequence: LSISTCRIMGVALVGRNKNP QMNFTEANEACKMLGLTLAS RDQVESAQKSGFETCSYGWV GEQFSVIPRIFSNPRCGKNG KGVLIWNAPSSQKFKAYCHN SSDTWVNSCIPEIVTTFYPV LDTQTPATEFSVSSSAYLAS SPDSTTPVSATTRAPPLTSM ARKTKKICITEVYTEPITMA TETEAFVASGAAFKNEAAG
Post Translational Modifications O-glycosylated.
Function Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium.
Protein Name Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1
Lyve-1
Cell Surface Retention Sequence-Binding Protein 1
Crsbp-1
Extracellular Link Domain-Containing Protein 1
Database Links Reactome: R-MMU-2160916
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Localized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal Compartments
Undergoes Ligand-Dependent Internalization And Recycling At The Cell Surface
Alternative Antibody Names Anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 antibody
Anti-Lyve-1 antibody
Anti-Cell Surface Retention Sequence-Binding Protein 1 antibody
Anti-Crsbp-1 antibody
Anti-Extracellular Link Domain-Containing Protein 1 antibody
Anti-Lyve1 antibody
Anti-Crsbp1 antibody
Anti-Xlkd1 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance