| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LYVE1 (20-322) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LYVE1 |
| Gene ID: |
10894 |
| Uniprot ID: |
LYVE1_HUMAN |
| Immunogen Region: |
20-322 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-322 of human LYVE1 (NP_006682.2). |
| Immunogen Sequence: |
LVQGSLRAEELSIQVSCRIM GITLVSKKANQQLNFTEAKE ACRLLGLSLAGKDQVETALK ASFETCSYGWVGDGFVVISR ISPNPKCGKNGVGVLIWKVP VSRQFAAYCYNSSDTWTNSC IPEIITTKDPIFNTQTATQT TEFIVSDSTYSVASPYSTIP APTTTPPAPASTSIPRRKKL ICVTEVFMETSTMSTETEPF VENKAAFKNEAAGFGGVPT |
| Tissue Specificity | Mainly expressed in endothelial cells lining lymphatic vessels. |
| Post Translational Modifications | O-glycosylated. |
| Function | Ligand-specific transporter trafficking between intracellular organelles (TGN) and the plasma membrane. Plays a role in autocrine regulation of cell growth mediated by growth regulators containing cell surface retention sequence binding (CRS). May act as a hyaluronan (HA) transporter, either mediating its uptake for catabolism within lymphatic endothelial cells themselves, or its transport into the lumen of afferent lymphatic vessels for subsequent re-uptake and degradation in lymph nodes. Binds to pericelluar hyaluronan matrices deposited on the surface of leukocytes and facilitates cell adhesion and migration through lymphatic endothelium. |
| Protein Name | Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1Lyve-1Cell Surface Retention Sequence-Binding Protein 1Crsbp-1Extracellular Link Domain-Containing Protein 1Hyaluronic Acid Receptor |
| Database Links | Reactome: R-HSA-2160916 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinLocalized To The Plasma Membrane And In Vesicles Near Extranuclear Membranes Which May Represent Trans-Golgi Network (Tgn) And Endosomes/Prelysosomeal CompartmentsUndergoes Ligand-Dependent Internalization And Recycling At The Cell SurfaceLocalizes At Cell-Cell Junctions |
| Alternative Antibody Names | Anti-Lymphatic Vessel Endothelial Hyaluronic Acid Receptor 1 antibodyAnti-Lyve-1 antibodyAnti-Cell Surface Retention Sequence-Binding Protein 1 antibodyAnti-Crsbp-1 antibodyAnti-Extracellular Link Domain-Containing Protein 1 antibodyAnti-Hyaluronic Acid Receptor antibodyAnti-LYVE1 antibodyAnti-CRSBP1 antibodyAnti-HAR antibodyAnti-XLKD1 antibodyAnti-UNQ230 antibodyAnti-PRO263 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
