| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Ly6/PLAUR domain-containing protein 8 (42-92 aa) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LYPD8 |
| Gene ID: |
646627 |
| Uniprot ID: |
LYPD8_HUMAN |
| Immunogen Region: |
42-92 aa |
| Specificity: |
This antibody detects endogenous levels of LYPD8 at Human/Mouse |
| Immunogen: |
Synthesized peptide derived from the human LYPD8 at the amino acid range 42-92 |
| Post Translational Modifications | Highly N-glycosylated. Not O-glycosylated. GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen. |
| Function | Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. |
| Protein Name | Ly6/Plaur Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted Into The Lumen Of The Colon Following Cleavage Of The Gpi-Anchor |
| Alternative Antibody Names | Anti-Ly6/Plaur Domain-Containing Protein 8 antibodyAnti-LYPD8 antibodyAnti-UNQ511 antibodyAnti-PRO1026 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
