| Post Translational Modifications | Highly N-glycosylated. Not O-glycosylated. GPI-anchored. The GPI-anchor is cleaved, leading to secretion into the colonic lumen. |
| Function | Secreted protein specifically required to prevent invasion of Gram-negative bacteria in the inner mucus layer of the colon epithelium, a portion of the large intestine which is free of commensal microbiota. Prevents invasion of flagellated microbiota by binding to the flagellum of bacteria, such as P.mirabilis, thereby inhibiting bacterial motility in the intestinal lumen. Segregation of intestinal bacteria and epithelial cells in the colon is required to preserve intestinal homeostasis. |
| Protein Name | Ly6/Plaur Domain-Containing Protein 8 |
| Database Links | Reactome: R-HSA-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-AnchorSecretedSecreted Into The Lumen Of The Colon Following Cleavage Of The Gpi-Anchor |
| Alternative Antibody Names | Anti-Ly6/Plaur Domain-Containing Protein 8 antibodyAnti-LYPD8 antibodyAnti-UNQ511 antibodyAnti-PRO1026 antibody |
Information sourced from Uniprot.org
