| Host: |
Rabbit |
| Applications: |
WB/IHC/IF/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-T-lymphocyte surface antigen Ly-9 (261-310 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:100-300ELISA 1:20000IF 1:50-200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LY9 |
| Gene ID: |
4063 |
| Uniprot ID: |
LY9_HUMAN |
| Immunogen Region: |
261-310 aa |
| Specificity: |
CD229 Polyclonal Antibody detects endogenous levels of CD229 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human LY9 at the amino acid range 261-310 |
| Function | Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins, SH2D1A/SAP and/or SH2D1B/EAT-2. May participate in adhesion reactions between T lymphocytes and accessory cells by homophilic interaction. Promotes T-cell differentiation into a helper T-cell Th17 phenotype leading to increased IL-17 secretion.the costimulatory activity requires SH2D1A. Promotes recruitment of RORC to the IL-17 promoter. May be involved in the maintenance of peripheral cell tolerance by serving as a negative regulator of the immune response. May disable autoantibody responses and inhibit IFN-gamma secretion by CD4(+) T-cells. May negatively regulate the size of thymic innate CD8(+) T-cells and the development of invariant natural killer T (iNKT) cells. |
| Protein Name | T-Lymphocyte Surface Antigen Ly-9Cell Surface Molecule Ly-9Lymphocyte Antigen 9Slam Family Member 3Slamf3Signaling Lymphocytic Activation Molecule 3Cd Antigen Cd229 |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-T-Lymphocyte Surface Antigen Ly-9 antibodyAnti-Cell Surface Molecule Ly-9 antibodyAnti-Lymphocyte Antigen 9 antibodyAnti-Slam Family Member 3 antibodyAnti-Slamf3 antibodyAnti-Signaling Lymphocytic Activation Molecule 3 antibodyAnti-Cd Antigen Cd229 antibodyAnti-LY9 antibodyAnti-CDABP0070 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
