| Function | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Also plays an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. |
| Protein Name | Lymphocyte Antigen 6eLy-6eStem Cell Antigen 2Thymic Shared Antigen 1Tsa-1 |
| Database Links | Reactome: R-MMU-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Lymphocyte Antigen 6e antibodyAnti-Ly-6e antibodyAnti-Stem Cell Antigen 2 antibodyAnti-Thymic Shared Antigen 1 antibodyAnti-Tsa-1 antibodyAnti-Ly6e antibodyAnti-Ly67 antibodyAnti-Sca-2 antibodyAnti-Tsa-1 antibody |
Information sourced from Uniprot.org
