Anti-LY6E-Mouse antibody (Internal) (STJ72310)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-LY6E-Mouse (Internal) is suitable for use in ELISA, Immunofluorescence, Flow Cytometry and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/IF/FC/IHC |
| Host | Goat |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:16000.IHC: Customer obtained staining in Mouse Placenta in a pattern consistent with in situ hybridisation results, and no staining in KO mice. This antibody has been successfully used in IHC on |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Accession Number | NP_002337.1; NP_032555.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | SCQEKDHYCIT |
| Specificity | Reported variants represent identical protein: NP_002337.1, NP_001120685.1 |
Additional Info
| Function | GPI-anchored cell surface protein that regulates T-lymphocytes proliferation, differentiation, and activation. Regulates the T-cell receptor (TCR) signaling by interacting with component CD3Z/CD247 at the plasma membrane, leading to CD3Z/CD247 phosphorylation modulation. Restricts the entry of murine coronavirus, mouse hepatitis virus, by interfering with spike protein-mediated membrane fusion. Plays also an essential role in placenta formation by acting as the main receptor for syncytin-A (SynA). Therefore, participates in the normal fusion of syncytiotrophoblast layer I (SynT-I) and in the proper morphogenesis of both fetal and maternal vasculatures within the placenta. May also act as a modulator of nicotinic acetylcholine receptors (nAChRs) activity. In vitro inhibits alpha-3:beta-4-containing nAChRs maximum response. |
| Protein Name | Lymphocyte Antigen 6eLy-6eStem Cell Antigen 2Thymic Shared Antigen 1Tsa-1 |
| Database Links | Reactome: R-MMU-163125 |
| Cellular Localisation | Cell MembraneLipid-AnchorGpi-Anchor |
| Alternative Antibody Names | Anti-Lymphocyte Antigen 6e antibodyAnti-Ly-6e antibodyAnti-Stem Cell Antigen 2 antibodyAnti-Thymic Shared Antigen 1 antibodyAnti-Tsa-1 antibodyAnti-Ly6e antibodyAnti-Ly67 antibodyAnti-Sca-2 antibodyAnti-Tsa-1 antibody |
Information sourced from Uniprot.org