| Short Description : | Rabbit polyclonal LTBP3 (1004-1303) antibody for use in WB and ELISA in rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | Lot specific |
| Purification: | Affinity purification |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LTBP3 |
| Gene ID: | 4054 |
| Uniprot ID: | LTBP3_HUMAN |
| Immunogen Region: | 1004-1303 |
| Immunogen Sequence: | ICKEGKCVNTQPGYECYCKQ GFYYDGNLLECVDVDECLDE SNCRNGVCENTRGGYRCACT PPAEYSPAQRQCLSPEEMDV DECQDPAACRPGRCVNLPGS YRCECRPPWVPGPSGRDCQL PESPAERAPERRDVCWSQRG EDGMCAGPLAGPALTFDDCC CRQGRGWGAQCRPCPPRGAG SHCPTSQSESNSFWDTSPLL LGKPPRDEDSSEEDSDECRC VSGRCVPRPGGAVCECPGG |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1004-1303 of human LTBP3 (NP_001123616.1). |
| Tissue Specificity | Isoform 2: Expressed prominently in heart, skeletal muscle, prostate, testis, small intestine and ovary. Isoform 1: Strongly expressed in pancreas and liver. |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 3Ltbp-3 |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-2173789 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSecretion Occurs After Coexpression With Tgfb1 And Requires Complexing With 'Cys-33' Of The Tgfb1 Propeptide |
| Alternative Antibody Names | Anti-Latent-Transforming Growth Factor Beta-Binding Protein 3 antibodyAnti-Ltbp-3 antibodyAnti-LTBP3 antibody |
Information sourced from Uniprot.org
