| Tissue Specificity | Isoform 2: Expressed prominently in heart, skeletal muscle, prostate, testis, small intestine and ovary. Isoform 1: Strongly expressed in pancreas and liver. |
| Post Translational Modifications | Contains hydroxylated asparagine residues. Two intrachain disulfide bonds from the TB3 domain are rearranged upon TGFB1 binding, and form interchain bonds with TGFB1 propeptide, anchoring it to the extracellular matrix. |
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. |
| Protein Name | Latent-Transforming Growth Factor Beta-Binding Protein 3Ltbp-3 |
| Database Links | Reactome: R-HSA-2129379Reactome: R-HSA-2173789 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular MatrixSecretion Occurs After Coexpression With Tgfb1 And Requires Complexing With 'Cys-33' Of The Tgfb1 Propeptide |
| Alternative Antibody Names | Anti-Latent-Transforming Growth Factor Beta-Binding Protein 3 antibodyAnti-Ltbp-3 antibodyAnti-LTBP3 antibody |
Information sourced from Uniprot.org
