| Host: | Rabbit |
| Applications: | IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leucine-rich repeat serine/threonine-protein kinase 1 (361-410 aa) is suitable for use in Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IHC 1:100-1:300 IF 1:200-1:1000 ELISA 1:5000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRK1 |
| Gene ID: | 79705 |
| Uniprot ID: | LRRK1_HUMAN |
| Immunogen Region: | 361-410 aa |
| Specificity: | LRRK1 Polyclonal Antibody detects endogenous levels of LRRK1 protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human LRRK1 at the amino acid range 361-410 |
| Function | Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts. |
| Protein Name | Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 |
| Cellular Localisation | Cytoplasm Cell Membrane Peripheral Membrane Protein |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 antibody Anti-LRRK1 antibody Anti-KIAA1790 antibody |
Information sourced from Uniprot.org