Anti-LRRK1 antibody (10-90) (STJ11104464)

Name: Anti-LRRK1 antibody (10-90) (STJ11104464)
SKU: STJ11104464
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11104464

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Short Description	Rabbit polyclonal Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 (10-90) antibody for use in WB and ELISA in human samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	LRRK1
Gene ID	79705
Uniprot ID	LRRK1_HUMAN
Immunogen Region	10-90
Immunogen Sequence	SMYWCVGPEESAVCPERAME TLNGAGDTGGKPSTRGGDPA ARSRRTEGIRAAYRRGDRGG ARDLLEEACDQCASQLEKGQ L
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 10-90 of human LRRK1 (NP_078928.3).

Post Translational Modifications	Autophosphorylated. Autophosphorylation is inhibited in its dimeric state. Phosphorylated by protein kinase C isozymes PRKCA, PRKCB, PRKCG, PRKCE, PRKCZ and PRKCT at Thr-1061, Ser-1064, Ser-1074 and Thr-1075. Phosphorylation at these Ser-1064, Ser-1074 and Thr-1075 activates the kinase activity of LRRK1 to phosphorylate RAB7A.
Function	Serine/threonine-protein kinase which phosphorylates RAB proteins involved in intracellular trafficking. Phosphorylates RAB7A.this activity is dependent on protein kinase C (PKC) activation. Plays a role in the negative regulation of bone mass, acting through the maturation of osteoclasts.
Protein Name	Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1
Database Links
Cellular Localisation	Cytoplasm Cell Membrane Peripheral Membrane Protein
Alternative Antibody Names	Anti-Leucine-Rich Repeat Serine/Threonine-Protein Kinase 1 antibody Anti-LRRK1 antibody Anti-KIAA1790 antibody

Information sourced from Uniprot.org