Anti-LRRFIP1 antibody (589-809) (STJ11105397)

Name: Anti-LRRFIP1 antibody (589-809) (STJ11105397)
SKU: STJ11105397
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⇓ Datasheet ⇓ SDS

SPECIFICATIONS

ClonalityPolyclonal

HostRabbit

ConjugationUnconjugated

IsotypeIgG

STJ11105397

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Short Description	Rabbit polyclonal Leucine-Rich Repeat Flightless-Interacting Protein 1 (589-809) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents.
Applications	WB/ELISA
Host	Rabbit
Reactivity	Human/Mouse/Rat
Note	STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.

Clonality	Polyclonal
Isotype	IgG
Conjugation	Unconjugated
Concentration	Lot specific
Purification	Affinity purification
Dilution Range	WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements.
Formulation	PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3.
Storage Instruction	Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.

Gene Symbol	LRRFIP1
Gene ID	9208
Uniprot ID	LRRF1_HUMAN
Immunogen Region	589-809
Immunogen Sequence	KDVKKELTYQNTDLSEIKEE EQVKSTDRKSAVEAQNEVTE NPKQKIAAESSENVDCPENP KIKLDGKLDQEGDDVQTAAE EVLADGDTLDFEDDTVQSSG PRAGGEELDEGVAKDNAKID GATQSSPAEPKSEDADRCTL PEHESPSQDISDACEAESTE RCEMSEHPSQTVRKALDSNS LENDDLSAPGREPGHFNPES REDTRGGNEKGKSKEDCTMS
Specificity	Recombinant fusion protein containing a sequence corresponding to amino acids 589-809 of human LRRFIP1 (NP_001131024.1).

Tissue Specificity	Ubiquitously expressed.
Function	Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding.
Protein Name	Leucine-Rich Repeat Flightless-Interacting Protein 1 Lrr Flii-Interacting Protein 1 Gc-Binding Factor 2 Tar Rna-Interacting Protein
Database Links	Reactome: R-HSA-1839117 Reactome: R-HSA-3134973 Reactome: R-HSA-5655302
Cellular Localisation	Nucleus Cytoplasm
Alternative Antibody Names	Anti-Leucine-Rich Repeat Flightless-Interacting Protein 1 antibody Anti-Lrr Flii-Interacting Protein 1 antibody Anti-Gc-Binding Factor 2 antibody Anti-Tar Rna-Interacting Protein antibody Anti-LRRFIP1 antibody Anti-GCF2 antibody Anti-TRIP antibody

Information sourced from Uniprot.org