| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:5000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRRFIP1 |
| Gene ID: | 9208 |
| Uniprot ID: | LRRF1_HUMAN |
| Immunogen Region: | 589-809 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 589-809 of human LRRFIP1 (NP_001131024.1). |
| Immunogen Sequence: | KDVKKELTYQNTDLSEIKEE EQVKSTDRKSAVEAQNEVTE NPKQKIAAESSENVDCPENP KIKLDGKLDQEGDDVQTAAE EVLADGDTLDFEDDTVQSSG PRAGGEELDEGVAKDNAKID GATQSSPAEPKSEDADRCTL PEHESPSQDISDACEAESTE RCEMSEHPSQTVRKALDSNS LENDDLSAPGREPGHFNPES REDTRGGNEKGKSKEDCTMS |
| Tissue Specificity | Ubiquitously expressed. |
| Function | Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding. |
| Protein Name | Leucine-Rich Repeat Flightless-Interacting Protein 1 Lrr Flii-Interacting Protein 1 Gc-Binding Factor 2 Tar Rna-Interacting Protein |
| Database Links | Reactome: R-HSA-1839117 Reactome: R-HSA-3134973 Reactome: R-HSA-5655302 |
| Cellular Localisation | Nucleus Cytoplasm |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Flightless-Interacting Protein 1 antibody Anti-Lrr Flii-Interacting Protein 1 antibody Anti-Gc-Binding Factor 2 antibody Anti-Tar Rna-Interacting Protein antibody Anti-LRRFIP1 antibody Anti-GCF2 antibody Anti-TRIP antibody |
Information sourced from Uniprot.org