Anti-LRRC32/GARP antibody [SAA0543] {APC} (STJA0029566)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationAPC
IsotypeIgG2ak
General Information
| Short Description | Mouse monoclonal Transforming Growth Factor Beta Activator Lrrc32 antibody for use in ELISA and FC in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA0543 |
| Isotype | IgG2ak |
| Conjugation | APC |
| Concentration | 0.5 mg/mL |
| Purification | Purified |
| Formulation | PBS pH 7.4, 50% glycerol, 0.05% proclin300 |
| Storage Instruction | Store at 4°C for 12 months. Protect from light. Do not freeze. |
Target Information
| Gene Symbol | LRRC32 |
| Gene ID | 2615 |
| Uniprot ID | LRC32_HUMAN |
Additional Info
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Activator Lrrc32 antibodyAnti-Garpin antibodyAnti-Glycoprotein A Repetitions Predominant antibodyAnti-Garp antibodyAnti-Leucine-Rich Repeat-Containing Protein 32 antibodyAnti-LRRC32 antibodyAnti-D11S833E antibody |
Information sourced from Uniprot.org