Anti-LRRC32 antibody (STJA0008873)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LRRC32
General Information
| Short Description | Rabbit polyclonal anti-Transforming growth factor beta activator LRRC32 for use in WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRRC32 |
| Gene ID | 2615 |
| Uniprot ID | LRC32_HUMAN |
| Immunogen | Synthesized peptide derived from human LRRC32 |
| Specificity | This antibody detects endogenous levels of LRRC32 at Human |
Additional Info
| Function | Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space. Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta. Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta. Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3). |
| Protein Name | Transforming Growth Factor Beta Activator Lrrc32GarpinGlycoprotein A Repetitions PredominantGarpLeucine-Rich Repeat-Containing Protein 32 |
| Database Links | |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinCell Surface |
| Alternative Antibody Names | Anti-Transforming Growth Factor Beta Activator Lrrc32 antibodyAnti-Garpin antibodyAnti-Glycoprotein A Repetitions Predominant antibodyAnti-Garp antibodyAnti-Leucine-Rich Repeat-Containing Protein 32 antibodyAnti-LRRC32 antibodyAnti-D11S833E antibody |
Information sourced from Uniprot.org