| Host: | Rabbit |
| Applications: | WB |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leucine-rich repeat protein 1 (116-166 aa) is suitable for use in Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-2000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LRR1 |
| Gene ID: | 122769 |
| Uniprot ID: | LLR1_HUMAN |
| Immunogen Region: | 116-166 aa |
| Specificity: | This antibody detects endogenous levels of LLR1 at Human |
| Immunogen: | Synthesized peptide derived from the human LLR1 at the amino acid range 116-166 |
| Function | Substrate recognition subunit of an ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. ECS(LRR1) ubiquitinates MCM7 and promotes CMG replisome disassembly by VCP and chromatin extraction during S-phase. May negatively regulate the 4-1BB-mediated signaling cascades which result in the activation of NK-kappaB and JNK1. |
| Protein Name | Leucine-Rich Repeat Protein 1 4-1bb-Mediated-Signaling Molecule 4-1bblrr Lrr-Repeat Protein 1 Lrr-1 Peptidylprolyl Isomerase-Like 5 |
| Database Links | Reactome: R-HSA-8951664 Reactome: R-HSA-983168 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Leucine-Rich Repeat Protein 1 antibody Anti-4-1bb-Mediated-Signaling Molecule antibody Anti-4-1bblrr antibody Anti-Lrr-Repeat Protein 1 antibody Anti-Lrr-1 antibody Anti-Peptidylprolyl Isomerase-Like 5 antibody Anti-LRR1 antibody Anti-PPIL5 antibody |
Information sourced from Uniprot.org