Anti-LRAT antibody (111-160 aa) (STJ93952)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human LRAT at the amino acid range 111-160
General Information
| Short Description | Rabbit polyclonal anti-Lecithin retinol acyltransferase (111-160 aa) for use in WB, IHC, IF and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IHC 1:100-1:300IF 1:200-1:1000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LRAT |
| Gene ID | 9227 |
| Uniprot ID | LRAT_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human LRAT at the amino acid range 111-160 |
| Immunogen Region | 111-160 aa |
| Specificity | LRAT Polyclonal Antibody detects endogenous levels of LRAT protein. |
Additional Info
| Function | Transfers the acyl group from the sn-1 position of phosphatidylcholine to all-trans retinol, producing all-trans retinyl esters. Retinyl esters are storage forms of vitamin A (Probable). LRAT plays a critical role in vision (Probable). It provides the all-trans retinyl ester substrates for the isomerohydrolase which processes the esters into 11-cis-retinol in the retinal pigment epithelium.due to a membrane-associated alcohol dehydrogenase, 11 cis-retinol is oxidized and converted into 11-cis-retinaldehyde which is the chromophore for rhodopsin and the cone photopigments (Probable). Required for the survival of cone photoreceptors and correct rod photoreceptor cell morphology. |
| Protein Name | Lecithin Retinol AcyltransferasePhosphatidylcholine--Retinol O-Acyltransferase |
| Database Links | Reactome: R-HSA-2453902Reactome: R-HSA-975634Reactome: R-HSA-9918442 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane ProteinRough Endoplasmic ReticulumEndosomeMultivesicular BodyCytoplasmPerinuclear RegionPresent In The Rough Endoplasmic Reticulum And Multivesicular Body In Hepatic Stellate CellsPresent In The Rough Endoplasmic Reticulum And Perinuclear Region In Endothelial Cells |
| Alternative Antibody Names | Anti-Lecithin Retinol Acyltransferase antibodyAnti-Phosphatidylcholine--Retinol O-Acyltransferase antibodyAnti-LRAT antibody |
Information sourced from Uniprot.org