| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Phosphatidate phosphatase LPIN1 is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LPIN1 |
| Gene ID: |
23175 |
| Uniprot ID: |
LPIN1_HUMAN |
| Specificity: |
This antibody detects endogenous levels of lipin1 ser889 at Human, Mouse, Rat |
| Immunogen: |
Synthesized peptide derived from human lipin1 ser889 |
| Tissue Specificity | Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. |
| Post Translational Modifications | Phosphorylated at multiple sites in response to insulin. Phosphorylation is controlled by the mTOR signaling pathway. Phosphorylation is decreased by epinephrine. Phosphorylation may not directly affect the catalytic activity but may regulate the localization. Dephosphorylated by the CTDNEP1-CNEP1R1 complex. Acetylation at Lys-425 and Lys-595 by KAT5 in response to fatty acids promotes translocation to the endoplasmic reticulum and synthesis of diacylglycerol. Sumoylated. |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. |
| Protein Name | Phosphatidate Phosphatase Lpin1Lipin-1 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-1483213Reactome: R-HSA-4419969Reactome: R-HSA-75109 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum MembraneNucleus MembraneTranslocates From The Cytosol To The Endoplasmic Reticulum Following Acetylation By Kat5 |
| Alternative Antibody Names | Anti-Phosphatidate Phosphatase Lpin1 antibodyAnti-Lipin-1 antibodyAnti-LPIN1 antibodyAnti-KIAA0188 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
