| Tissue Specificity | Specifically expressed in skeletal muscle. Also abundant in adipose tissue. Lower levels in some portions of the digestive tract. |
| Post Translational Modifications | Phosphorylated at multiple sites by mTOR in response to insulin, leading to its inactivation. Phosphorylation does not affect the catalytic activity but regulates the localization. Phosphorylation is decreased by epinephrine. Dephosphorylated by the CTDNEP1-CNEP1R1 complex. Dephosphorylation following mTOR inhibition promotes its activity. Acetylation at Lys-425 and Lys-595 by KAT5 in response to fatty acids promotes translocation to the endoplasmic reticulum and synthesis of diacylglycerol. Sumoylated. |
| Function | Acts as a magnesium-dependent phosphatidate phosphatase enzyme which catalyzes the conversion of phosphatidic acid to diacylglycerol during triglyceride, phosphatidylcholine and phosphatidylethanolamine biosynthesis and therefore controls the metabolism of fatty acids at different levels. Is involved in adipocyte differentiation. Recruited at the mitochondrion outer membrane and is involved in mitochondrial fission by converting phosphatidic acid to diacylglycerol. Acts also as nuclear transcriptional coactivator for PPARGC1A/PPARA regulatory pathway to modulate lipid metabolism gene expression. |
| Protein Name | Phosphatidate Phosphatase Lpin1Lipin-1 |
| Database Links | Reactome: R-HSA-1483191Reactome: R-HSA-1483213Reactome: R-HSA-4419969Reactome: R-HSA-75109 |
| Cellular Localisation | CytoplasmCytosolEndoplasmic Reticulum MembraneNucleus MembraneTranslocates From The Cytosol To The Endoplasmic Reticulum Following Acetylation By Kat5 |
| Alternative Antibody Names | Anti-Phosphatidate Phosphatase Lpin1 antibodyAnti-Lipin-1 antibodyAnti-LPIN1 antibodyAnti-KIAA0188 antibody |
Information sourced from Uniprot.org
