| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LOXL4 |
| Gene ID: | 84171 |
| Uniprot ID: | LOXL4_HUMAN |
| Immunogen Region: | 25-280 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 25-280 of human LOXL4 (NP_115587.6). |
| Immunogen Sequence: | QSLGTTKLRLVGPESKPEEG RLEVLHQGQWGTVCDDNFAI QEATVACRQLGFEAALTWAH SAKYGQGEGPIWLDNVRCVG TESSLDQCGSNGWGVSDCSH SEDVGVICHPRRHRGYLSET VSNALGPQGRRLEEVRLKPI LASAKQHSPVTEGAVEVKYE GHWRQVCDQGWTMNNSRVVC GMLGFPSEVPVDSHYYRKVW DLKMRDPKSRLKSLTNKNSF WIHQVTCLGTEPHMANCQV |
| Tissue Specificity | Expressed in many tissues, the highest levels among the tissues studied being in the skeletal muscle, testis and pancreas. Expressed in cartilage. |
| Post Translational Modifications | The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine. May be proteolytically cleaved by BMP1. |
| Function | Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers. |
| Protein Name | Lysyl Oxidase Homolog 4Lysyl Oxidase-Like Protein 4Lysyl Oxidase-Related Protein C |
| Database Links | Reactome: R-HSA-1566948Reactome: R-HSA-2243919 |
| Cellular Localisation | SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Lysyl Oxidase Homolog 4 antibodyAnti-Lysyl Oxidase-Like Protein 4 antibodyAnti-Lysyl Oxidase-Related Protein C antibodyAnti-LOXL4 antibodyAnti-LOXC antibody |
Information sourced from Uniprot.org