| Host: | Rabbit |
| Applications: | WB/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LORICRIN |
| Gene ID: | 4014 |
| Uniprot ID: | LORI_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human LORICRIN (NP_000418.2). |
| Immunogen Sequence: | MSYQKKQPTPQPPVDCVKTS GGGGGGGGSGGGGCGFFGGG GSGGGSSGSGCGYSGGGGYS GGGCGGGSSGGGGGGGIGGC GGGSGGSVKYSGGGGSSGGG |
| Post Translational Modifications | Substrate of transglutaminases. Some glutamines and lysines are cross-linked to other loricrin molecules and to SPRRs proteins. Contains inter- or intramolecular disulfide-bonds. |
| Function | Major keratinocyte cell envelope protein. |
| Protein Name | Loricrin |
| Database Links | Reactome: R-HSA-6809371Reactome: R-HSA-9725554 |
| Cellular Localisation | CytoplasmNucleusNucleoplasm |
| Alternative Antibody Names | Anti-Loricrin antibodyAnti-LORICRIN antibodyAnti-LOR antibodyAnti-LRN antibody |
Information sourced from Uniprot.org