Anti-LONP2 antibody (1-300) (STJ118354)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal LONP2 (1-300) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LONP2 |
| Gene ID | 83752 |
| Uniprot ID | LONP2_HUMAN |
| Immunogen Region | 1-300 |
| Immunogen Sequence | MSSVSPIQIPSRLPLLLTHE GVLLPGSTMRTSVDSARNLQ LVRSRLLKGTSLQSTILGVI PNTPDPASDAQDLPPLHRIG TAALAVQVVGSNWPKPHYTL LITGLCRFQIVQVLKEKPYP IAEVEQLDRLEEFPNTCKMR EELGELSEQFYKYAVQLVEM LDMSVPAVAKLRRLLDSLPR EALPDILTSIIRTSNKEKLQ ILDAVSLEERFKMTIPLLVR QIEGLKLLQKTRKPKQDDD |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-300 of human LONP2 (NP_113678.2). |
Additional Info
| Tissue Specificity | Widely expressed, with high levels in the liver, kidney and pancreas. |
| Function | ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import. May indirectly regulate peroxisomal fatty acid beta-oxidation through degradation of the self-processed forms of TYSND1. |
| Protein Name | Lon Protease Homolog 2 - PeroxisomalLon Protease-Like Protein 2Lon Protease 2Peroxisomal Lon ProteasePlon |
| Database Links | Reactome: R-HSA-390471Reactome: R-HSA-9033241 |
| Cellular Localisation | Peroxisome Matrix |
| Alternative Antibody Names | Anti-Lon Protease Homolog 2 - Peroxisomal antibodyAnti-Lon Protease-Like Protein 2 antibodyAnti-Lon Protease 2 antibodyAnti-Peroxisomal Lon Protease antibodyAnti-Plon antibodyAnti-LONP2 antibodyAnti-LONP antibody |
Information sourced from Uniprot.org