| Host: | Goat |
| Applications: | Pep-ELISA/WB |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Goat polyclonal antibody anti-LNK/SH2B3 (N-Term) is suitable for use in ELISA and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Purification: | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Concentration: | 0.5 mg/mL |
| Dilution Range: | Peptide ELISA: antibody detection limit dilution 1:64000.WB: Approx 70kDa band observed in lysates of cell line MOLT4 (calculated MW of 63.2kDa according to NP_005466.1). In transfected HEK293 transiently expressing SH2B3 a band of approx. 65kDa |
| Storage Instruction: | Store at-20°C on receipt and minimise freeze-thaw cycles. |
| Gene Symbol: | SH2B3 |
| Gene ID: | 10019 |
| Uniprot ID: | SH2B3_HUMAN |
| Immunogen Region: | N-Term |
| Accession Number: | NP_005466.1 |
| Immunogen Sequence: | NGPALQPSSPC |
| Post Translational Modifications | Tyrosine phosphorylated by LCK. |
| Function | Links T-cell receptor activation signal to phospholipase C-gamma-1, GRB2 and phosphatidylinositol 3-kinase. |
| Protein Name | Sh2b Adapter Protein 3Lymphocyte Adapter ProteinLymphocyte-Specific Adapter Protein LnkSignal Transduction Protein Lnk |
| Database Links | Reactome: R-HSA-1433559Reactome: R-HSA-9706369Reactome: R-HSA-983231 |
| Alternative Antibody Names | Anti-Sh2b Adapter Protein 3 antibodyAnti-Lymphocyte Adapter Protein antibodyAnti-Lymphocyte-Specific Adapter Protein Lnk antibodyAnti-Signal Transduction Protein Lnk antibodyAnti-SH2B3 antibodyAnti-LNK antibody |
Information sourced from Uniprot.org