| Host: | Mouse |
| Applications: | WB/IHC/IF/IP |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Lamin-B1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 7C11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | WB 1:2000-5000IP 1:200IF 1:200IHC 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMNB1 |
| Gene ID: | 4001 |
| Uniprot ID: | LMNB1_HUMAN |
| Specificity: | The antibody detects endogenous Lamin B1 protein. |
| Immunogen: | Recombinant Protein of Lamin-B1 |
| Function | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. |
| Protein Name | Lamin-B1 |
| Database Links | Reactome: R-HSA-1221632Reactome: R-HSA-2559584Reactome: R-HSA-2980766Reactome: R-HSA-2995383Reactome: R-HSA-352238Reactome: R-HSA-4419969Reactome: R-HSA-8862803Reactome: R-HSA-8950505Reactome: R-HSA-9013405Reactome: R-HSA-9035034 |
| Cellular Localisation | Nucleus Lamina |
| Alternative Antibody Names | Anti-Lamin-B1 antibodyAnti-LMNB1 antibodyAnti-LMN2 antibodyAnti-LMNB antibody |
Information sourced from Uniprot.org