| Host: | Mouse |
| Applications: | WB/IHC/IF/IP |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Mouse monoclonal antibody anti-Lamin-B1 is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and Immunoprecipitation research applications. |
| Clonality : | Monoclonal |
| Clone ID : | 7C11 |
| Conjugation: | Unconjugated |
| Isotype: | IgG1 |
| Formulation: | Liquid in PBS pH7.4, 0.5% BSA, 0.02% Sodium Azide and 50% Glycerol. |
| Purification: | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
| Dilution Range: | WB 1:2000-5000 IP 1:200 IF 1:200 IHC 1:50-300 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LMNB1 |
| Gene ID: | 4001 |
| Uniprot ID: | LMNB1_HUMAN |
| Specificity: | The antibody detects endogenous Lamin B1 protein. |
| Immunogen: | Recombinant Protein of Lamin-B1 |
| Function | Lamins are intermediate filament proteins that assemble into a filamentous meshwork, and which constitute the major components of the nuclear lamina, a fibrous layer on the nucleoplasmic side of the inner nuclear membrane. Lamins provide a framework for the nuclear envelope, bridging the nuclear envelope and chromatin, thereby playing an important role in nuclear assembly, chromatin organization, nuclear membrane and telomere dynamics. The structural integrity of the lamina is strictly controlled by the cell cycle, as seen by the disintegration and formation of the nuclear envelope in prophase and telophase, respectively. |
| Protein Name | Lamin-B1 |
| Database Links | Reactome: R-HSA-1221632 Reactome: R-HSA-2559584 Reactome: R-HSA-2980766 Reactome: R-HSA-2995383 Reactome: R-HSA-352238 Reactome: R-HSA-4419969 Reactome: R-HSA-8862803 Reactome: R-HSA-8950505 Reactome: R-HSA-9013405 Reactome: R-HSA-9035034 |
| Cellular Localisation | Nucleus Lamina |
| Alternative Antibody Names | Anti-Lamin-B1 antibody Anti-LMNB1 antibody Anti-LMN2 antibody Anti-LMNB antibody |
Information sourced from Uniprot.org