• STJ73569 (1µg/ml) staining of HeLa (A) and NIH3T3 (B) lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.
  • STJ73569 (0. 3µg/ml) staining of Rat Pancreas lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-LIMK2 antibody (181-193) (STJ73569)

SKU:
STJ73569-100

£303.50
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Host: Goat
Applications: Pep-ELISA/WB
Reactivity: Human/Mouse/Rat/Pig
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-LIMK2 (181-193) is suitable for use in ELISA and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: ELISA-antibody detection limit dilution 1:16000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: LIMK2
Gene ID: 3985
Uniprot ID: LIMK2_HUMAN
Immunogen Region: 181-193
Accession Number: NP_001026971.1; NP_005560.1; NP_057952.1
Specificity: This antibody is expected to recognize all reported isoforms (NP_001026971.1; NP_005560.1; NP_057952.1).
Immunogen Sequence: QVKEVNRMHISPN
Function Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Involved in astral microtubule organization and mitotic spindle orientation during early stages of mitosis by mediating phosphorylation of TPPP. Displays serine/threonine-specific phosphorylation of myelin basic protein and histone (MBP) in vitro. Suppresses ciliogenesis via multiple pathways.phosphorylation of CFL1, suppression of directional trafficking of ciliary vesicles to the ciliary base, and by facilitating YAP1 nuclear localization where it acts as a transcriptional corepressor of the TEAD4 target genes AURKA and PLK1.
Protein Name Lim Domain Kinase 2
Limk-2
Database Links Reactome: R-HSA-3928662
Reactome: R-HSA-416572
Reactome: R-HSA-5627117
Cellular Localisation Cytoplasm
Cytoskeleton
Spindle
Microtubule Organizing Center
Centrosome
Isoform Limk2a: Cytoplasm
Nucleus
Isoform Limk2b: Cytoplasm
Perinuclear Region
Mainly Present In The Cytoplasm And Is Scarcely Translocated To The Nucleus
Alternative Antibody Names Anti-Lim Domain Kinase 2 antibody
Anti-Limk-2 antibody
Anti-LIMK2 antibody

Information sourced from Uniprot.org

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