| Tissue Specificity | Detected in macrophages, splenocytes and B lymphocytes (at protein level). Detected in macrophages, mast cells, splenocytes, peritoneal cells and natural killer cells. |
| Post Translational Modifications | Phosphorylated on tyrosine residues by LYN. Phosphorylation at Tyr-794 and Tyr-824 is important for interaction with PTPN6/SHP-1 and PTPN11/SHP-2. |
| Function | May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM). |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3Lir-3Leukocyte Immunoglobulin-Like Receptor 3Cell-Surface Glycoprotein P91Paired Immunoglobulin-Like Receptor BPir-B |
| Database Links | Reactome: R-MMU-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 3 antibodyAnti-Lir-3 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 3 antibodyAnti-Cell-Surface Glycoprotein P91 antibodyAnti-Paired Immunoglobulin-Like Receptor B antibodyAnti-Pir-B antibodyAnti-Lilrb3 antibodyAnti-Pirb antibody |
Information sourced from Uniprot.org
