| Host: |
Rabbit |
| Applications: |
WB/ELISA |
| Reactivity: |
Human/Rat/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Leukocyte immunoglobulin-like receptor subfamily B member 2 (121-170 aa) is suitable for use in Western Blot and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000ELISA 1:10000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LILRB2 |
| Gene ID: |
10288 |
| Uniprot ID: |
LIRB2_HUMAN |
| Immunogen Region: |
121-170 aa |
| Specificity: |
CD85d Polyclonal Antibody detects endogenous levels of CD85d protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the Internal region of human LILRB2 at the amino acid range 121-170 |
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Involved in the down-regulation of the immune response and the development of tolerance. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M) triggering differentiation of type 1 regulatory T cells and myeloid-derived suppressor cells, both of which actively maintain maternal-fetal tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2Lir-2Leukocyte Immunoglobulin-Like Receptor 2Cd85 Antigen-Like Family Member DImmunoglobulin-Like Transcript 4Ilt-4Monocyte/Macrophage Immunoglobulin-Like Receptor 10Mir-10Cd Antigen Cd85d |
| Database Links | Reactome: R-HSA-198933Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 2 antibodyAnti-Lir-2 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 2 antibodyAnti-Cd85 Antigen-Like Family Member D antibodyAnti-Immunoglobulin-Like Transcript 4 antibodyAnti-Ilt-4 antibodyAnti-Monocyte/Macrophage Immunoglobulin-Like Receptor 10 antibodyAnti-Mir-10 antibodyAnti-Cd Antigen Cd85d antibodyAnti-LILRB2 antibodyAnti-ILT4 antibodyAnti-LIR2 antibodyAnti-MIR10 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
