Anti-LILRB1 antibody (21-70 aa) (STJ97291)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB1 at the amino acid range 21-70
General Information
| Short Description | Rabbit polyclonal anti-Leukocyte immunoglobulin-like receptor subfamily B member 1 (21-70 aa) for use in WB and IHC in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LILRB1 |
| Gene ID | 10859 |
| Uniprot ID | LIRB1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the N-terminal region of human LILRB1 at the amino acid range 21-70 |
| Immunogen Region | 21-70 aa |
| Specificity | LIR-1 Polyclonal Antibody detects endogenous levels of LIR-1 protein. |
Additional Info
| Post Translational Modifications | Phosphorylated on tyrosine residues. Dephosphorylated by PTPN6. |
| Function | Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C, HLA-G and HLA-F alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of FCER1A signaling and serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide. Upon interaction with peptide-bound HLA-G-B2M complex, triggers secretion of growth-promoting factors by decidual NK cells. Reprograms B cells toward an immune suppressive phenotype. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1Lir-1Leukocyte Immunoglobulin-Like Receptor 1Cd85 Antigen-Like Family Member JImmunoglobulin-Like Transcript 2Ilt-2Monocyte/Macrophage Immunoglobulin-Like Receptor 7Mir-7Cd Antigen Cd85j |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 5: Secreted |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily B Member 1 antibodyAnti-Lir-1 antibodyAnti-Leukocyte Immunoglobulin-Like Receptor 1 antibodyAnti-Cd85 Antigen-Like Family Member J antibodyAnti-Immunoglobulin-Like Transcript 2 antibodyAnti-Ilt-2 antibodyAnti-Monocyte/Macrophage Immunoglobulin-Like Receptor 7 antibodyAnti-Mir-7 antibodyAnti-Cd Antigen Cd85j antibodyAnti-LILRB1 antibodyAnti-ILT2 antibodyAnti-LIR1 antibodyAnti-MIR7 antibody |
Information sourced from Uniprot.org