| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Leukocyte immunoglobulin-like receptor subfamily A member 4 (391-440 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC-P 1:100-300 ELISA 1:20000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LILRA4 |
| Gene ID: | 23547 |
| Uniprot ID: | LIRA4_HUMAN |
| Immunogen Region: | 391-440 aa |
| Specificity: | CD85g Polyclonal Antibody detects endogenous levels of CD85g protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the Internal region of human LILRA4 at the amino acid range 391-440 |
| Function | Functions coreceptor to limit the innate immune responses to viral infections.signaling occurs via FCER1G. Down-regulates the production of IFNA1, IFNA2, IFNA4, IFNB1 and TNF by plasmacytoid dendritic cells that have been exposed to influenza virus or cytidine-phosphate-guanosine (CpG) dinucleotides, indicating it functions as a negative regulator of TLR7 and TLR9 signaling cascades. Down-regulates interferon production in response to interaction with BST2 on HIV-1 infected cells. Activates a signaling cascade in complex with FCER1G that results in phosphorylation of Src family and Syk kinases and thereby triggers mobilization of intracellular Ca(2+). Does not interfere with the differentiation of plasmacytoid dendritic cells into antigen-presenting cells. |
| Protein Name | Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 Cd85 Antigen-Like Family Member G Immunoglobulin-Like Transcript 7 Ilt-7 Cd Antigen Cd85g |
| Database Links | Reactome: R-HSA-198933 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Immunoglobulin-Like Receptor Subfamily A Member 4 antibody Anti-Cd85 Antigen-Like Family Member G antibody Anti-Immunoglobulin-Like Transcript 7 antibody Anti-Ilt-7 antibody Anti-Cd Antigen Cd85g antibody Anti-LILRA4 antibody Anti-ILT7 antibody |
Information sourced from Uniprot.org