| Host: | Rabbit |
| Applications: | IHC/WB |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-LGI1 (300-350 aa) is suitable for use in Immunohistochemistry and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Lyophilised |
| Purification: | IgG purified |
| Dilution Range: | IHC, WB (confirmed by recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not tested in other applications. |
| Storage Instruction: | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
| Gene Symbol: | LGI1 |
| Gene ID: | 9211 |
| Uniprot ID: | LGI1_HUMAN |
| Immunogen Region: | 300-350 aa |
| Specificity: | Specific for LGI1. |
| Immunogen: | A synthetic peptide from aa region 300-350 of mouse LGI1 conjugated to blue carrier protein was used as the antigen. The peptide is homologous in rat and human. |
| Post Translational Modifications | Glycosylated. |
| Function | Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors. Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway. May play a role in the control of neuroblastoma cell survival. |
| Protein Name | Leucine-Rich Glioma-Inactivated Protein 1Epitempin-1 |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | SecretedSynapseCytoplasmIsoform 1: Golgi ApparatusIsoform 2: Endoplasmic Reticulum |
| Alternative Antibody Names | Anti-Leucine-Rich Glioma-Inactivated Protein 1 antibodyAnti-Epitempin-1 antibodyAnti-LGI1 antibodyAnti-EPT antibodyAnti-UNQ775 antibodyAnti-PRO1569 antibody |
Information sourced from Uniprot.org