| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LECT1 (75-334) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
CNMD |
| Gene ID: |
11061 |
| Uniprot ID: |
CNMD_HUMAN |
| Immunogen Region: |
75-334 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 75-334 of human LECT1 (NP_008946.1). |
| Immunogen Sequence: |
VHYTMSINGKLQDGSMEIDA GNNLETFKMGSGAEEAIAVN DFQNGITGIRFAGGEKCYIK AQVKARIPEVGAVTKQSISS KLEGKIMPVKYEENSLIWVA VDQPVKDNSFLSSKVLELCG DLPIFWLKPTYPKEIQRERR EVVRKIVPTTTKRPHSGPRS NPGAGRLNNETRPSVQEDSQ AFNPDNPYHQQEGESMTFDP RLDHEGICCIECRRSYTHCQ KICEPLGGYYPWPYNYQGC |
| Tissue Specificity | Detected in cartilage and cardiac valves (at protein level). Detected in the laminae fibrosa, spongiosa and ventricularis layers of normal cardiac valves (at protein level). Expression is decreased cardiac valves of patients with valvular heart disease (at protein level). Weakly expressed in chondrosarcoma. |
| Post Translational Modifications | After cleavage, the post-translationally modified ChM-I is secreted as a glycoprotein. |
| Function | Bifunctional growth regulator that stimulates the growth of cultured chondrocytes in the presence of basic fibroblast growth factor (FGF) but inhibits the growth of cultured vascular endothelial cells. May contribute to the rapid growth of cartilage and vascular invasion prior to the replacement of cartilage by bone during endochondral bone development. Inhibits in vitro tube formation and mobilization of endothelial cells. Plays a role as antiangiogenic factor in cardiac valves to suppress neovascularization. |
| Protein Name | Leukocyte Cell-Derived Chemotaxin 1Chondromodulin Cleaved Into - Chondrosurfactant ProteinCh-Sp - Chondromodulin-1Chondromodulin-IChm-I |
| Cellular Localisation | Chondromodulin-1: SecretedExtracellular SpaceExtracellular MatrixAccumulated In The Inter-Territorial Matrix Of CartilageChondrosurfactant Protein: Endomembrane SystemSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Leukocyte Cell-Derived Chemotaxin 1 antibodyAnti-Chondromodulin Cleaved Into - Chondrosurfactant Protein antibodyAnti-Ch-Sp - Chondromodulin-1 antibodyAnti-Chondromodulin-I antibodyAnti-Chm-I antibodyAnti-CNMD antibodyAnti-CHMI antibodyAnti-LECT1 antibodyAnti-MYETS1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Confocal immunofluorescence analysis of HeLa cells using [KO Validated] AIF Rabbit polyclonal antibody (STJ22557) at dilution of 1:200. Blue: DAPI for nuclear staining.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/99099/383657/STJ22557_1__70141.1713152204.jpg?c=1 "Confocal immunofluorescence analysis of HeLa cells using [KO Validated] AIF Rabbit polyclonal antibody (STJ22557) at dilution of 1:200. Blue: DAPI for nuclear staining.")