| Host: | Rabbit |
| Applications: | WB/IHC-P/IF/ICC/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:2000 IHC-P:1:50-1:200 IF/ICC:1:50-1:200 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | LDLR |
| Gene ID: | 3949 |
| Uniprot ID: | LDLR_HUMAN |
| Immunogen Region: | 761-860 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 761-860 of human LDL Receptor (LDLR) (NP_000518.1). |
| Immunogen Sequence: | TVEIVTMSHQALGDVAGRGN EKKPSSVRALSIVLPIVLLV FLCLGVFLLWKNWRLKNINS INFDNPVYQKTTEDEVHICH NQDGYSYPSRQMVSLEDDVA |
| Post Translational Modifications | N- and O-glycosylated. Ubiquitinated by MYLIP leading to degradation. |
| Function | Binds low density lipoprotein /LDL, the major cholesterol-carrying lipoprotein of plasma, and transports it into cells by endocytosis. In order to be internalized, the receptor-ligand complexes must first cluster into clathrin-coated pits. Forms a ternary complex with PGRMC1 and TMEM97 receptors which increases LDLR-mediated LDL internalization. (Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes, but not through a direct interaction with viral proteins. (Microbial infection) Acts as a receptor for Vesicular stomatitis virus. (Microbial infection) In case of HIV-1 infection, may function as a receptor for extracellular Tat in neurons, mediating its internalization in uninfected cells. (Microbial infection) Acts as a receptor for Crimean-Congo hemorrhagic fever virus (CCHFV). (Microbial infection) Acts as a receptor for many Alphavirus, including Getah virus (GETV), Ross river virus (RRV) and Semliki Forest virus. |
| Protein Name | Low-Density Lipoprotein Receptor Ldl Receptor |
| Database Links | Reactome: R-HSA-8856825 Reactome: R-HSA-8856828 Reactome: R-HSA-8964026 Reactome: R-HSA-8964038 Reactome: R-HSA-975634 |
| Cellular Localisation | Cell Membrane Single-Pass Type I Membrane Protein Membrane Clathrin-Coated Pit Golgi Apparatus Early Endosome Late Endosome Lysosome Rapidly Endocytosed Upon Ligand Binding Localized At Cell Membrane Probably In Lipid Rafts In Serum-Starved Conditions |
| Alternative Antibody Names | Anti-Low-Density Lipoprotein Receptor antibody Anti-Ldl Receptor antibody Anti-LDLR antibody |
Information sourced from Uniprot.org