• Anti-Lck-interacting molecule antibody [LIME-10] (STJ16100293)

Anti-Lck-interacting molecule antibody [LIME-10] (STJ16100293)

SKU:
STJ16100293-01

£521.50
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Host: Mouse
Applications: WB/IHC-P
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Mouse monoclonal antibody anti-Lck-interacting molecule is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Monoclonal
Clone ID: LIME-10
Conjugation: Unconjugated
Isotype: IgG2a
Formulation: Phosphate buffered saline (PBS) solution with 15 mM sodium azide
Concentration: 1 mg/mL
Storage Instruction: Store at 2-8°C upon receipt.
Gene Symbol: LIME1
Gene ID: 54923
Uniprot ID: LIME1_HUMAN
Immunogen: COOH-terminal peptide comprising residues 281-296 of the human LIME conjugated to keyhole limpet hemocyanin.
Tissue Specificity Expressed in peripheral blood lymphocytes, lymphoid tissues, and liver. Present in T-cells and plasma cells, and in various hematopoietic cell lines (at protein level).
Post Translational Modifications Palmitoylation of Cys-28 and Cys-31 is required for raft targeting. Phosphorylated on tyrosines upon TCR activation and/or CD4 coreceptor stimulation, or upon BCR stimulation.which leads to the recruitment of SH2-containing proteins.
Function Involved in BCR (B-cell antigen receptor)-mediated signaling in B-cells and TCR (T-cell antigen receptor)-mediated T-cell signaling in T-cells. In absence of TCR signaling, may be involved in CD4-mediated inhibition of T-cell activation. Couples activation of these receptors and their associated kinases with distal intracellular events such as calcium mobilization or MAPK activation through the recruitment of PLCG2, GRB2, GRAP2, and other signaling molecules.
Protein Name Lck-Interacting Transmembrane Adapter 1
Lck-Interacting Membrane Protein
Lck-Interacting Molecule
Cellular Localisation Cell Membrane
Single-Pass Type Iii Membrane Protein
Present In Lipid Rafts
Recruited To The Immunological Synapse Upon Conjugation Of T-Cell With Antigen-Presenting Cell
Alternative Antibody Names Anti-Lck-Interacting Transmembrane Adapter 1 antibody
Anti-Lck-Interacting Membrane Protein antibody
Anti-Lck-Interacting Molecule antibody
Anti-LIME1 antibody
Anti-LIME antibody
Anti-LP8067 antibody

Information sourced from Uniprot.org

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