Anti-LARP7 antibody (360-410) {FITC} (STJ501576)

SKU:
STJ501576-100

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Host: Rabbit
Applications: ELISA/IP/WB
Reactivity: Human
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-LARP7 (360-410) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: FITC
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.50-0.75 µg/µl
Dilution Range: WB: 1:500
DB: 1:4, 000
ELISA: 1:4, 000
IP: 1:150
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: LARP7
Gene ID: 51574
Uniprot ID: LARP7_HUMAN
Immunogen Region: 360-410
Immunogen: Synthetic peptide taken within amino acid region 360-410 on human LARP7 protein.
Function RNA-binding protein that specifically binds distinct small nuclear RNA (snRNAs) and regulates their processing and function. Specifically binds the 7SK snRNA (7SK RNA) and acts as a core component of the 7SK ribonucleoprotein (RNP) complex, thereby acting as a negative regulator of transcription elongation by RNA polymerase II. The 7SK RNP complex sequesters the positive transcription elongation factor b (P-TEFb) in a large inactive 7SK RNP complex preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation. The 7SK RNP complex also promotes snRNA gene transcription by RNA polymerase II via interaction with the little elongation complex (LEC). LARP7 specifically binds to the highly conserved 3'-terminal U-rich stretch of 7SK RNA.on stimulation, remains associated with 7SK RNA, whereas P-TEFb is released from the complex. LARP7 also acts as a regulator of mRNA splicing fidelity by promoting U6 snRNA processing. Specifically binds U6 snRNAs and associates with a subset of box C/D RNP complexes: promotes U6 snRNA 2'-O-methylation by facilitating U6 snRNA loading into box C/D RNP complexes. U6 snRNA 2'-O-methylation is required for mRNA splicing fidelity. Binds U6 snRNAs with a 5'-CAGGG-3' sequence motif. U6 snRNA processing is required for spermatogenesis.
Protein Name La-Related Protein 7
La Ribonucleoprotein Domain Family Member 7
Hlarp7
P-Tefb-Interaction Protein For 7sk Stability
Pip7s
Cellular Localisation Nucleus
Nucleoplasm
Alternative Antibody Names Anti-La-Related Protein 7 antibody
Anti-La Ribonucleoprotein Domain Family Member 7 antibody
Anti-Hlarp7 antibody
Anti-P-Tefb-Interaction Protein For 7sk Stability antibody
Anti-Pip7s antibody
Anti-LARP7 antibody
Anti-HDCMA18P antibody

Information sourced from Uniprot.org

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