| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-LARP1 (106-205) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
LARP1 |
| Gene ID: |
23367 |
| Uniprot ID: |
LARP1_HUMAN |
| Immunogen Region: |
106-205 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 106-205 of human LARP1 (Q6PKG0). |
| Immunogen Sequence: |
AGAAGAGRRDFVEAPPPKVN PWTKNALPPVLTTVNGQSPP EHSAPAKVVRAAVPKQRKGS KVGDFGDAINWPTPGEIAHK SVQPQSHKPQPTRKLPPKKD |
| Post Translational Modifications | Phosphorylated on multiple Ser and Thr residues in response to active mTORC1. Phosphorylation is important for interaction with RPTOR and the mTORC1 complex. Phosphorylation promotes dissociation from the 5'UTR of mRNA molecules with a 5'TOP motif. |
| Function | RNA-binding protein that regulates the translation of specific target mRNA species downstream of the mTORC1 complex, in function of growth signals and nutrient availability. Interacts on the one hand with the 3' poly-A tails that are present in all mRNA molecules, and on the other hand with the 7-methylguanosine cap structure of mRNAs containing a 5' terminal oligopyrimidine (5'TOP) motif, which is present in mRNAs encoding ribosomal proteins and several components of the translation machinery. The interaction with the 5' end of mRNAs containing a 5'TOP motif leads to translational repression by preventing the binding of EIF4G1. When mTORC1 is activated, LARP1 is phosphorylated and dissociates from the 5' untranslated region (UTR) of mRNA. Does not prevent binding of EIF4G1 to mRNAs that lack a 5'TOP motif. Interacts with the free 40S ribosome subunit and with ribosomes, both monosomes and polysomes. Under normal nutrient availability, interacts primarily with the 3' untranslated region (UTR) of mRNAs encoding ribosomal proteins and increases protein synthesis. Associates with actively translating ribosomes and stimulates translation of mRNAs containing a 5'TOP motif, thereby regulating protein synthesis, and as a consequence, cell growth and proliferation. Stabilizes mRNAs species with a 5'TOP motif, which is required to prevent apoptosis. (Microbial infection) Positively regulates the replication of dengue virus (DENV). |
| Protein Name | La-Related Protein 1La Ribonucleoprotein Domain Family Member 1 |
| Database Links | Reactome: R-HSA-9705671 |
| Cellular Localisation | CytoplasmCytoplasmic GranuleColocalizes With Rptor And Pabpc1 In Cytoplasmic Granules That Resemble Stress Granules |
| Alternative Antibody Names | Anti-La-Related Protein 1 antibodyAnti-La Ribonucleoprotein Domain Family Member 1 antibodyAnti-LARP1 antibodyAnti-KIAA0731 antibodyAnti-LARP antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
