Anti-LARGE antibody (421-433) (STJ72207)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-LARGE (421-433) is suitable for use in ELISA and Western Blot research applications. |
| Applications | Pep-ELISA/WB |
| Host | Goat |
| Reactivity | Human/Dog/Cow |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:2000.WB: Approx 75kDa band observed in Human Kidney, and Heart lysates (calculated MW of 88.1kDa according to NP_004728.1). Recommended concentration: 1-3ยตg/ml. |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20ยฐC on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | LARGE1 |
| Gene ID | 9215 |
| Uniprot ID | LARG1_HUMAN |
| Accession Number | NP_004728.1 |
| Immunogen Region | 421-433 |
| Immunogen Sequence | SEADVNSENLQKQ |
| Specificity | Reported variants represent identical protein: NP_004728.1, NP_598397.1 |
Additional Info
| Function | Bifunctional glycosyltransferase with both alpha-1,3-xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the maturation of alpha-dystroglycan (DAG1) by glycosylation leading to DAG1 binding to laminin G-like domain-containing extracellular proteins with high affinity. Elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B4GAT1 by adding repeating units -3-Xylose-alpha-1,3-GlcA-beta-1- to produce a heteropolysaccharide. Requires the phosphorylation of core M3 (O-mannosyl trisaccharide) by POMK to elongate the glucuronyl-beta-1,4-xylose-beta disaccharide primer. Plays a key role in skeletal muscle function and regeneration. |
| Protein Name | Xylosyl- And Glucuronyltransferase Large1Acetylglucosaminyltransferase-Like 1aGlycosyltransferase-Like ProteinLarge Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 |
| Database Links | Reactome: R-HSA-5083627Reactome: R-HSA-5173105 |
| Cellular Localisation | Golgi Apparatus MembraneSingle-Pass Type Ii Membrane Protein |
| Alternative Antibody Names | Anti-Xylosyl- And Glucuronyltransferase Large1 antibodyAnti-Acetylglucosaminyltransferase-Like 1a antibodyAnti-Glycosyltransferase-Like Protein antibodyAnti-Large Xylosyl- And Glucuronyltransferase 1 Includes - Alpha-1 -3-Xylosyltransferase Large1 - Beta-1 -3-Glucuronyltransferase Large1 antibodyAnti-LARGE1 antibodyAnti-KIAA0609 antibodyAnti-LARGE antibody |
Information sourced from Uniprot.org