Anti-LAPTM4B antibody (STJA0007096)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human LAPTM4B
General Information
| Short Description | Rabbit polyclonal anti-Lysosomal-associated transmembrane protein 4B for use in WB in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | LAPTM4B |
| Gene ID | 55353 |
| Uniprot ID | LAP4B_HUMAN |
| Immunogen | Synthesized peptide derived from human LAPTM4B |
| Specificity | This antibody detects endogenous levels of LAPTM4B at Human, Mouse, Rat |
Additional Info
| Function | Required for optimal lysosomal function. Blocks EGF-stimulated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, regulates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation. Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stimulating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation. Plays a role as negative regulator of TGFB1 production in regulatory T cells. Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways. |
| Protein Name | Lysosomal-Associated Transmembrane Protein 4bLysosome-Associated Transmembrane Protein 4-Beta |
| Database Links | |
| Cellular Localisation | Endomembrane SystemMulti-Pass Membrane ProteinLate Endosome MembraneCell MembraneCell ProjectionLysosome MembraneEndosome MembraneEndosomeMultivesicular Body MembraneMultivesicular Body Lumen |
| Alternative Antibody Names | Anti-Lysosomal-Associated Transmembrane Protein 4b antibodyAnti-Lysosome-Associated Transmembrane Protein 4-Beta antibodyAnti-LAPTM4B antibodyAnti-PSEC0001 antibody |
Information sourced from Uniprot.org